Evaluating the Nephrotoxicity of Exemplar Compounds Using a Mechanistic Model of Drug-Induced Acute Kidney Injury
Keywords: Acute kidney injury (AKI), mechanistic model, nephrotoxicity, quantitative systems toxicology (QST) modelSoftware: RENAsym™Conference: American Society of Nephrology (ASN)Division: DILIsym Services
Background
- Drug-induced nephrotoxicity is a common source of acute kidney injury (AKI) and a condition that complicates clinical outcomes of vulnerable patients.
- Drugs cause nephrotoxicity by various cellular mechanisms, including mitochondrial dysfunction, oxidative stress, and others.
- Predicting the toxicity and injury mechanisms of drugs remains a challenge.
- We utilized a quantitative systems toxicology (QST) model to evaluate the nephrotoxicity and underlying mechanisms of two positive (cisplatin and gentamicin) and one negative (acetaminophen) control exemplar compounds
By Yeshitila Gebremichael, Jeffery L. Woodhead, Nader Hamzavi, Shailendra Tallapaka, Scott Q. Siler, and Brett A. Howell
2019 ASN Kidney Week, November 5-10, 2019, Washington, DC
