Food effect: The combined effect of media pH and viscosity on the gastrointestinal absorption of ciprofloxacin tablet

Authors: Radwan A, Zaid AN, Jaradat N, Odeh Y
Publication: Eur J Pharm Sci
Keywords: ciprofloxacin, corchorus olitorius, food effect, oral absorption, physiological modeling, viscosity
Software: GastroPlus®

Background

The clinical implications of food-drug interactions may have to be taken seriously into account with oral drugs administration in order to minimize variations in drug bioavailability. Food intake may alter physiological changes in the pH and viscosity of the gastrointestinal lumen, which could affect the oral absorption of drugs.