Navicixizumab: Strategically Designed for Efficacy and Safety
•Navicixizumab is a first-in-class, bispecific, anti-angiogenic antibody to vascular endothelial growth factor (VEGF) and delta-like ligand 4 (DLL4) in the Notch pathway
•Designed to overcome VEGF resistance and more potent than targeting either DLL4 or VEGF alone
•Designed to retain potent antitumor effects while reducing risks associated with DLL4 inhibition
•Designed to downregulate DDL4-Notch signaling in tumors and both Notch and VEGF pathways in angiogenesis
By, Jessica K Roberts, Heather Barcomb, Kevin Dykstra, and Kerry Culm.
Poster presented at the Society of Gynecologic Oncology (SGO) 2022 Annual Meeting on Women’s Cancer; March 18 – 21, 2022; Phoenix, AZ.