Generalized PBPK Model for Evaluation of Inhalation Exposure of Volatile Organic Compounds

Authors: Mullin JM, Amini E, Lawless M, Lukacova V, Bolger MB
Conference: SOT
Keywords: inhalation, live stream learning, PBPK modeling, pulmonary playlist, vapor inhalation, volatile organic compounds
Software: GastroPlus®
Division: Simulations Plus

Introduction

Physiologically based pharmacokinetic modeling (PBPK) is a valuable tool to evaluate inhalation exposure of volatile organic compounds (VOCs). Many literature models are ad hoc, built for a single purpose/molecule, include small subset of tissues, and rely on experimental or fitted partition coefficients. In this work, a standardized PBPK modeling platform GastroPlus® (Simulations Plus, Inc.) is utilized to develop a PBPK model for vapor inhalation. Previously, the inhalation capability was focused on dry powder, nebulized, or solution formulations. The focus of this work is building a model to describe vapor inhalation and validating its usage.

By James Mullin, Elham Amini, Michael Lawless, Viera Lukacova, Michael B. Bolger

Canceled: SOT 59th Annual Meeting & ToxExpo March 15-19. 2020 in Anaheim, California