Physiologically based pharmacokinetic modeling (PBPK) is a valuable tool to evaluate inhalation exposure of volatile organic compounds (VOCs). Many literature models are ad hoc, built for a single purpose/molecule, include small subset of tissues, and rely on experimental or fitted partition coefficients. In this work, a standardized PBPK modeling platform GastroPlus® (Simulations Plus, Inc.) is utilized to develop a PBPK model for vapor inhalation. Previously, the inhalation capability was focused on dry powder, nebulized, or solution formulations. The focus of this work is building a model to describe vapor inhalation and validating its usage.
By James Mullin, Elham Amini, Michael Lawless, Viera Lukacova, Michael B. Bolger
Canceled: SOT 59th Annual Meeting & ToxExpo March 15-19. 2020 in Anaheim, California