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Apr 2, 2018
  |  Presentation

How to Understand Aqueous Ionization and Its Influence on Key Physical Properties of Drugs

Outline

  • Part I: Clearing Up Myths About Aqueous Ionization of Drugs
    • Myth #1: apparent pKa can always be “assigned” to functional groups
    • Myth #2: apparent pKa can always be “labeled” as either acidic, or basic
  • Part II: Understanding the pH Dependence of Aqueous Solubility
  • Part III: Understanding the pH Dependence of Partitioning

Cambridge Healthtech’s Drug Discovery Chemistry 2018, April 3-5,2018, San Diego, CA

By Robert Fraczkiewicz

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