pKa has many impacts in drug discovery, such as:
- Affects absorption, distribution, metabolism and excretion
- Safety profile (off-targets liabilities, e.g. hERG inhibition)
- Binding with membranes, membrane analogs and proteins.
- Can affect drug-receptor binding (salt-bridge formation, desolvation)
- Useful in formulation, manufacturing and process control pKa is the key parameter for other physchem properties, such as
By Dr. Michael Reutlinger