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May 7, 2019
  |  Presentation

In Silico and in Vitro Simulations to Predict Idiosyncratic DILI: What is on the Horizon?

DILIsym Tool Overview

  • Multiple species: human, rat, mouse, and dog
    • Population variability
  • The three primary acinar zones of liver represented
  • Essential cellular processes represented to multiple scales in interacting submodels
  • Over 60 detailed representations of optimization or validation compounds with 80% success
  • Single and combination drug therapies

US FDA & AASLD DILI Conference at the University of Maryland University College May 7-8, 2019

By Brett Howell

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