Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer’s disease

Authors: Cherif O, Allouche F, Chabchoub F, Chioua M, Soriano E, Yáñez M, Cacabelos R, Romero A, López MG, Marco-Contelles J
Publication: Future Med Chem
Keywords: acetylcholinesterase, alzheimer disease, butyrylcholinesterase, cell survival, cholinesterase, HEK293 cells, Hep G2 cells, humans, isoxazoles, molecular docking simulation, protein binding, recombinant proteins, tacrine
Software: ADMET Predictor®

Background

Owing to the complex nature of Alzheimer’s disease, there is a renewed and growing search for multitarget non-toxictacrines as simple, easily available drugs in order to stop the progress and development of the disease.