Mechanistic Investigation of Negative Food Effect for BCS Class III Compounds in Solid Dosage Forms
Keywords: aqueous solubility, dissolution media, drug release, gastrointestinal, water diffusivitySoftware: GastroPlus®Publication: Mol Pharm
Much interest has been expressed in this work on the role of water diffusivity in the release media as a new parameter for predicting drug release. NMR was used to measure water diffusivity in different media varying in their osmolality and viscosity. Water self-diffusion coefficients in sucrose, sodium chloride and polymeric HPMC solutions were correlated with water uptakes, disintegration as well as drug release rates from trospium chloride immediate release tablets. Water diffusivity in sucrose solutions was significantly reduced compared to polymeric HPMC and molecular sodium chloride solutions. Water diffusivity was found to be a function of sucrose concentration in the media. Dosage form disintegration and drug release was to be affected by water diffusivity in these systems. This observation can be explained by hydrogen bonding formation between sugar molecules, an effect which was not expressed in sodium chloride solutions of equal osmolality. Water diffusivity and not media osmolality in general need to be considered to predict the effect of disintegration and dissolution media on drug release. Understanding the relevance of water diffusivity for disintegration and dissolution will lead to better parameterization of dosage form behaviour in gastrointestinal aqueous and semisolid media.