Mechanistic investigation of the negative food effect of modified release zolpidem

Publication: Eur J Pharm Sci
Software: GastroPlus®


When administered orally as either an immediate or modified release dosage form, zolpidem demonstrates a negative foodeffect, i.e. decrease in Cmax and AUC. The aim of the study was to arrive at a better understanding of the absorption of this BCS class I compound in vivo and to simulate the observed plasma profiles using in vitro and in silico methods.