Mechanistic Modelling of the Linkage Between Proximal Tubule Cell Sublethal Injury and Tubular Sodium Reabsorption Impairment

Conference: American Society of Nephrology (ASN)
Software: RENAsym®
Division: DILIsym Services


  • Sublethal renal epithelial cell injury, a key manifestation of drug-induced acute kidney injury (AKI), is characterized by loss of brush border and cellular polarity of proximal tubular cells (PTCs).
  • The key cellular alterations caused by sublethal injury involve impaired energetics and associated disruptions in cytoskeletal structure and sodium transporters activity.
  • Our objective is to develop a mechanistic model relating cellular injury of AKI with renal tubular dysfunction needed to represent the complexity of renal pathophysiology.

By Nader Hamzavi, Brett A. Howell, Jeffrey L. Woodhead, Shailendra Tallapaka, Scott Q. Siler, and Yeshitila Gebremichael

2019 ASN Kidney Week, November 5-10, 2019, Washington, DC