MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

Publication: Pharm Res
Software: MITOsym®
Division: DILIsym Services


MITOsym, a new mathematical model of hepatocellular respiration and bioenergetics, has been developed in partnership with the DILIsym® model with the purpose of translating in vitro compound screening data into predictions of drug induced liver injury (DILI) risk for patients. The combined efforts of these two models should increase the efficiency of evaluating compounds in drug development in addition to enhancing patient care.

By Jeffery Woodhead, Brett A Howell, Paul B. Watkins, Scott Q Siler