Modeling of Cilostazol absorption and pharmacokinetics in Beagle Dogs and design of in-vitro dissolution experiment to model the in-vivo absorption

Authors: Lukacova V, Prabhakaran A, Woltosz WS, Bolger MB
Conference: AAPS
Keywords: beagle dogs, Cilostazol, In vitro in vivo correlations (IVIVC), liver metabolism
Software: ADMET Predictor®
Division: Simulations Plus

Purpose

The purpose of this study was to evaluate the in-vitro/in-vivo (IVIV) correlationfor a Class II compound and to design an in-vitro dissolution experimentthat improves this IVIV correlation by taking into account the sink created by the removal of dissolved drug from the intestinal lumen due to high permeability.

AAPS (American Association of Pharmaceutical Scientists) Annual Meeting, November 13-17, 2016, Denver, CO

By Viera Lukacova, Walter S Woltosz, Michael B Bolger