Modeling of Cilostazol absorption and pharmacokinetics in Beagle Dogs and design of in-vitro dissolution experiment to model the in-vivo absorption

Conference: AAPS
Software: ADMET Predictor®
Division: Simulations Plus


The purpose of this study was to evaluate the in-vitro/in-vivo (IVIV) correlationfor a Class II compound and to design an in-vitro dissolution experimentthat improves this IVIV correlation by taking into account the sink created by the removal of dissolved drug from the intestinal lumen due to high permeability.

AAPS (American Association of Pharmaceutical Scientists) Annual Meeting, November 13-17, 2016, Denver, CO

By Viera Lukacova, Walter S Woltosz, Michael B Bolger