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    Jun 1, 2012
      |  Journal Article

    Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions

    Xia B, Heimbach T, Lin T, He H, Wang Y, Tan E
    Keywords: animals, antineoplastic agents, autoradiography, biological models, epothilones, humans, liver microsomes, metabolism, ratsSoftware: GastroPlus®Publication: Cancer Chemother Pharmacol

    Purpose

    Patupilone (EPO906) is a novel potent microtubule stabilizer, which has been evaluated for cancer treatment. A novel physiologically based pharmacokinetics (PBPK) model was developed based on nonclinical data to predict the disposition of patupilone in cancer patients.

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