Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions
Keywords: animals, antineoplastic agents, autoradiography, biological models, epothilones, humans, liver microsomes, metabolism, ratsSoftware: GastroPlus®Publication: Cancer Chemother Pharmacol
Purpose
Patupilone (EPO906) is a novel potent microtubule stabilizer, which has been evaluated for cancer treatment. A novel physiologically based pharmacokinetics (PBPK) model was developed based on nonclinical data to predict the disposition of patupilone in cancer patients.