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Jun 1, 2012

Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions

Purpose

Patupilone (EPO906) is a novel potent microtubule stabilizer, which has been evaluated for cancer treatment. A novel physiologically based pharmacokinetics (PBPK) model was developed based on nonclinical data to predict the disposition of patupilone in cancer patients.

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