Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions

Publication: Cancer Chemother Pharmacol
Software: GastroPlus®


Patupilone (EPO906) is a novel potent microtubule stabilizer, which has been evaluated for cancer treatment. A novel physiologically based pharmacokinetics (PBPK) model was developed based on nonclinical data to predict the disposition of patupilone in cancer patients.