After investing years into developing and optimizing a new drug, it’s some of the worst news you can hear: your clinical trials are showing potential liver toxicity. 

Could you have prevented this? And what steps can you take now to try to rescue your drug? 

The DILIsym® liver safety prediction platform is a quantitative systems toxicology (QST) tool used for liver safety assessment, and can be utilized at any time during your drug development program. It serves to provide insight about your compound and de-risks it for regulatory submissions. In this webinar, you’ll learn how several clients have strategically used DILIsym to overcome challenges and achieve their development goals. Presenters will also discuss how QST predictions can be used earlier in the drug development process to increase the likelihood of program success, as well as how they can help guide future R&D goals.

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Novice & Advanced Users
Workshops

ACoP14 Nov. 5th -8th National Harbor, MD

• Booth #15
• Session 5C Symposium: Latest Innovations in Model-Informed Precision Dosing Around the World
  Chair and Panel Moderator: Amparo de la Peña
• Roller Coaster Session 2: Two novel fast and reliable automated covariate search methods: COSSAC and SAMBA
  Presenter: Claude Magnard
  Presentation: Development of an Ocular PBPK-PD model to predict drug-mediated intraocular pressure reduction in preclinical species.
  Presenter: Maxime Le Merdy
• Presentation: Accelerating a QSP Model of Nonalcoholic Steatohepatitis (NASH) using the Julia Language
  Presenter: Matthew McDaniel
• Presentation: ILDsym®, a Quantitative Systems Pharmacology (QSP) Platform, Successfully Simulates Efficacy of Key Treatments for Systemic Sclerosis-Interstitial Lung Disease
  Presenter: Zack Kenz
• Post-meeting workshop: Pharmacometrics Modeling & Simulations Using MonolixSuite: From Introductory to Advanced Concepts and Applications
  Presenter: Dr. Monika Twarogowska

American College of Toxicology (ACT) Annual Meeting Nov. 12th -15th Orlando, FL

• Booth #102
• Attendees: Josh Fohey & Brett Howell
• Presentation: Quantitative Systems Toxicology (QST) Modeling Using a New Virtual Population in BIOLOGXsym Offers Mechanistic Insights Into Bile Acid-mediated Biologics-induced Liver Injury (BILI) Upon Cimaglermin Alfa (GGF2) Administration
  Presenter: Brett Howell
• Awards Ceremony Keynote: Dr. Paul Watkins, Distinguished Scientist

International Congress of Pharmaceutical (CIFRAP) 2023 Nov. 15th-18th Ribeirão Preto, Brazil

• Presentation: Integration of Artificial Intelligence and Physiologically Based Biopharmaceutic Models on the Development of Extended-Release Formulations
  Presenter: Frederico Martins

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Latest Offers

• Unleash the power of AI for early drug discovery
• Streamline PBPK and QSP workflows with our Pulmonary Package
• Train your team during your next consulting project with Consult + Coach

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Stay Informed
On Demand Webinars

• Ionization Prediction Summit Webinar Series: Session 1 Fundamentals of Ionization
• Capture and Use of Meaningful Data for Population PK/PD Analysis with Non-Linear Mixed Effects Modeling 
• From Target Identification to Novel Lead: How Multi-omics Analysis and AI-driven Drug Design Can Accelerate Early Drug Discovery 

Can’t Miss

Upcoming Webinars

• Ionization Prediction Summit Webinar Series: Session 4 – Experimental Aspects of pKa Measurements
• Using QST Predictions to Optimize Your Drug, De-Risk Your Regulatory Submission, and Guide R&D

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Stay Informed
On Demand Webinars

• Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats 
• Can an Amine Be a Weaker and a Stronger Base at the Same Time? Curious Cases of Chameleonic Ionization 
• The First Physiologically Based Pharmacokinetic (PBPK) Model for an Oral Vaccine Using Alpha-Tocopherol as an Adjuvant 

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