A Pharmacokinetic Simulation-Based Comparison Of Varying Adherence Rates For Paliperidone ER And Risperidone In Patients With Schizophrenia
Medication adherence is important to successful management of • patients with schizophrenia and related psychotic disorders; patient nonadherence is documented in numerous studies (e.g., 30%-35% patient noncompliance).1,2 Drug formulation affects the pharmacokinetic (PK) profile and plays • an important role in maintaining therapeutic plasma concentrations.
Paliperidone extended-release (ER) and risperidone have similar • pharmacologic effects with regard to D2 receptor occupancy.3,4 Compared with risperidone, however, paliperidone ER formulation has a longer elimination half-life5 and less peak-to-trough fluctuations at steady state.
PK simulations using clinical study population data provide a novel • methodology to compare drug plasma concentrations following different adherence rates. PK simulations were performed to examine the impact of various • adherence rates during chronic therapy with paliperidone ER and risperidone.
U.S. Psychiatric and Mental Health Congress, Las Vegas, Nevada, November 2009
By C.L. DeVane; Julie Passarell; Jill Fiedler-Kelly; Elizabeth A. Ludwig; L. Martinez; C.M. Canuso