PK/PD Modeling of Adinazolam

Conference: AAPS
Software: ADMET Predictor®
Division: Simulations Plus


Develop a model for prediction of the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of Adinazolam from IV, immediate release oral, and controlled release oral formulations. Estimate the effects of variability in absorption, pharmacokinetic and pharmacodynamic parameters on PD response.

American Association of Pharmaceutical Scientist Annual Meeting and Exposition, November 12-14, 2007

By Viera Lukacova, Walter S Woltosz, Michael B Bolger