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Apr 2, 2008
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Population Pharmacokinetics of Bendamustine and Metabolites in Patients With Indolent Non-Hodgkin Lymphoma

Introduction

  • Bendamustine is a bifunctional alkylating agent in development as monotherapy and in combination with other agents in the treatment of indolent non-Hodgkin lymphoma (NHL):
    • Synthesized to combine the act ivi t ies of a purine antimetabolite (benzimidazole) with the a lkyl a t ing prope r t i e s of the bi func t iona l mechlorethamine nitrogen mustard1,2
    • Converted in vivo to active metabolites: γ-hydroxy bendamustine (M3) and N-desmethyl bendamustine (M4)
  • The precise mechanism of action of bendamustine in humans has not been fully characterized, although it differs from other alkylating agents.

American Society for Clinical Pharmacology and Therapeutics (ASCPT); Orlando, Florida; April 2008

By Joel S. Owen, M. Melhem, D. D’Andrea, M. Darwish

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