Predicting PK of Multisource Acyclovir Oral Products Through PBBM Modeling

Software: GastroPlus®
Division: Simulations Plus


Highly variable disposition after oral ingestion of acyclovir has been reported, although little is known regarding the underlying mechanisms. Different studies using the same reference product (Zovirax ®) showed that Cmax and AUC were respectively 44 and 35% lower in Saudi Arabians than Europeans, consistent with higher frequencies of reduced-activity polymorphs of the organic cation transporter (OCT1) in Europeans. This webinar will explore this study in depth.

Presenters: Dr. Peter Langguth, University Professor at Johannes Gutenberg University Mainz Dr. Mauricio A. Garcia, PhD student/Research Assistant, Johannes Gutenberg University Mainz