Progress in Prediction and Interpretation of Clinically Relevant Metabolic Drug-Drug Interactions: a Minireview Illustrating Recent Developments and Current Opportunities

Authors: Fowler S, Morcos PN, Cleary Y, Martin-Facklam M, Parrott N, Gertz M, Yu L
Publication: Curr Pharmacol Rep
Keywords: cytochrome P450 (CYP), drug–drug interaction, metabolism, physiologically based pharmacokinetic modeling, prediction, regulatory submission
Software: GastroPlus®

Purpose of Review

This review gives a perspective on the current “state of the art” in metabolic drug-drug interaction (DDI) prediction. We highlight areas of successful prediction and illustrate progress in areas where limits in scientific knowledge or technologies prevent us from having full confidence.