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May 22, 2021
  |  Presentation

Pulmonary PBPK Modeling for Inhaled Products: Antibiotic Case Studies

What are we doing for inhaled products today?

Ability to assess exposure/concentration in any tissue

  • Assessment of therapeutic dose & dose range by linking simulated plasma or tissue concentrations to PD effect
  • Evaluation of formulation effects through Parameter Sensitivity Analysis
    • Dosage form
    • Particle size
    • Distribution
    • Density
    • Shape factor
  • Prediction of population variability through the Population Simulator mode

By James Mullin

Presented at 2021 ISAM Congress held in Boise, Idaho, USA, May 22-26, 2021

 

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