Pulmonary PBPK Modeling for Inhaled Products: Antibiotic Case Studies

Authors: Mullin JM
Conference: 2021 ISAM Congress
Keywords: antibiotics, gastroplus, PBPK modeling, PBPK studies, sensitivity analysis
Software: GastroPlus®
Division: Simulations Plus

What are we doing for inhaled products today?

Ability to assess exposure/concentration in any tissue

  • Assessment of therapeutic dose & dose range by linking simulated plasma or tissue concentrations to PD effect
  • Evaluation of formulation effects through Parameter Sensitivity Analysis
    • Dosage form
    • Particle size
    • Distribution
    • Density
    • Shape factor
  • Prediction of population variability through the Population Simulator mode

By James Mullin

Presented at 2021 ISAM Congress held in Boise, Idaho, USA, May 22-26, 2021