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Oct 28, 2020
  |  Presentation

Quantitative Systems Toxicology (QST) Modeling of Drug-Induced Liver Injury and Adaptation

Description

  • This talk will present how quantitative systems toxicology (QST) modeling can aid in evaluating potential drug-drug interactions (DDIs) at the hepatotoxicity mechanism level and exploring mechanisms underlying adaptation to drug-induced liver injury (DILI)
  • A case study will be presented where DILIsym, a QST modeling platform, was employed to assess potential DILI DDIs between metformin and solithromycin.

Presented at AAPS PharmSci 360 Oct. 26- Nov. 5, 2020

By Kyunghee Yang

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