Quantitative Systems Toxicology (QST) Modeling of Drug-Induced Liver Injury and Adaptation
Keywords: DDIs, DILI, DILIsym, hepatotoxicity, QST modelingSoftware: DILIsym®Conference: AAPSDivision: DILIsym Services
- This talk will present how quantitative systems toxicology (QST) modeling can aid in evaluating potential drug-drug interactions (DDIs) at the hepatotoxicity mechanism level and exploring mechanisms underlying adaptation to drug-induced liver injury (DILI)
- A case study will be presented where DILIsym, a QST modeling platform, was employed to assess potential DILI DDIs between metformin and solithromycin.
Presented at AAPS PharmSci 360 Oct. 26- Nov. 5, 2020
By Kyunghee Yang