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Dec 5, 2014
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Relationship Between Eslicarbazepine Exposure and Safety Endpoints for Eslicarbazepine Acetate Adjunctive Therapy

Introduction

  • Eslicarbazepine acetate (ESL) is a once-daily (QD) oral antiepileptic drug (AED), approved in the US, Canada and the EU as adjunctive treatment of partial-onset seizures (POS).
  • After oral administration, ESL is extensively and rapidly converted to its major active metabolite, eslicarbazepine.1
  • Data from three randomized controlled Phase III trials (studies 2093-301, -302 and -304) showed that adjunctive ESL (400–1200 mg QD) was generally well tolerated by patients with POS.2
  • The current analysis uses data from the above studies to examine the relationship between eslicarbazepine exposure and the incidence of the most frequently occurring treatment-emergent adverse events (TEAEs) during adjunctive use of ESL.

American Epilepsy Society (AES) Annual Meeting, December 5-9, 2014, Seattle, WA

By Patricia Penovich, Gregory Krauss, Michael R. Sperling, Salvatore Striano, Christian Elger, Julie A Passarell, Jill Fiedler-Kelly, Elizabeth A Ludwig, Soujanya Sunkaraneni, Rui Sousa, Francisco Rocha, David Blum

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