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Aug 1, 2015

Role of Self-Association and Supersaturation in Oral Absorption of a Poorly Soluble Weakly Basic Drug

Purpose

Precipitation of weakly basic drugs in intestinal fluids can affect oral drug absorption. In this study, the implications of self-association of brivanib alaninate in acidic aqueous solution, leading to supersaturation at basic pH condition, on its solubility and oral absorption were investigated.

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