The use of gastrointestinal intubation studies for controlled release development
Keywords: administration and dosage, animals, colon physiology, dogs, gastrointestinal, humans, intestinal absorption, permeability, solubilitySoftware: GastroPlus®Publication: Br J Clin Pharmacol
Aims
This review describes clinical results of gastrointestinal intubation studies of eight controlled release (CR) candidates under development during the 1990s and offers suggestions for determining why, when and how to conduct human intubation studies.