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    Sep 1, 2009
      |  Journal Article

    The use of gastrointestinal intubation studies for controlled release development

    Sutton SC
    Keywords: administration and dosage, animals, colon physiology, dogs, gastrointestinal, humans, intestinal absorption, permeability, solubilitySoftware: GastroPlus®Publication: Br J Clin Pharmacol

    Aims

    This review describes clinical results of gastrointestinal intubation studies of eight controlled release (CR) candidates under development during the 1990s and offers suggestions for determining why, when and how to conduct human intubation studies.

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