The use of gastrointestinal intubation studies for controlled release development

Authors: Sutton SC
Publication: Br J Clin Pharmacol
Keywords: administration and dosage, animals, colon physiology, dogs, gastrointestinal, humans, intestinal absorption, permeability, solubility
Software: GastroPlus®

Aims

This review describes clinical results of gastrointestinal intubation studies of eight controlled release (CR) candidates under development during the 1990s and offers suggestions for determining why, when and how to conduct human intubation studies.