Utilizing pKa Values for Effective Crop Protection: On Systemicity and Efficacy of Molecules

Authors: Grimbs S
Keywords: agrochemicals, crop protection, drug discovery, early drug development, Ionization Constants (pKa), Ionization Prediction Summit
Software: ADMET Predictor®

Importance of crop protection

  • Significant yield losses from weeds, diseases, and pests necessitate crop protection
  • Key pest categories include chewing, sucking, and soil-based pests
  • Crop protection molecules must reach target

Goal: increase efficacy by increase systemicity – pKa as a major driver

By Florian Häse, Nina Kausch-Busies, Kai Sommer, Sergio Grimbs