What does it take to develop a PBPK model that mimics in vivo behavior of LAIs? Part II

Authors: Lukacova V
Conference: LAI Conference
Keywords: gastroplus, in vivo, long-acting injectable formulations, PBPK modeling
Software: GastroPlus®
Division: Simulations Plus

Outline

This presentation will take a closer look at possible mechanisms affecting behavior of suspensions of low solubility drugs

  • PBPK model description
  • Effect of dissolution rate Example Cabotegravir
  • Effect of changing depot volume Example Paliperidone Palmitate

By Viera Lukacova

3rd Long-Acting Injectables & Implantables Conference in La Jolla, California February 6, 2020