A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways

Authors: Phillips MB, Leonard JA, Grulke CM, Edwards SW, Chang DT, Brooks R, Goldsmith MR, El-Masri HA, Tan YM
Publication: Environ Health Perspect
Keywords: acetylcholinesterase, cholinesterase inhibitors, high-throughput screening (HTS), humans, in vitro techniques, metabolism, pharmacokinetics, risk assessment
Software: ADMET Predictor®

Background

Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, along with absorption, distribution, metabolism, and excretion (ADME) properties of chemicals.