A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways
Keywords: acetylcholinesterase, cholinesterase inhibitors, high-throughput screening (HTS), humans, in vitro techniques, metabolism, pharmacokinetics, risk assessmentSoftware: ADMET Predictor®Publication: Environ Health Perspect
Background
Adverse outcome pathways (AOPs) link adverse effects in individuals or populations to a molecular initiating event (MIE) that can be quantified using in vitro methods. Practical application of AOPs in chemical-specific risk assessment requires incorporation of knowledge on exposure, along with absorption, distribution, metabolism, and excretion (ADME) properties of chemicals.
