You can provide Vmax and Km values for each enzyme/ transporter independently, or you can lump them into a single effective Vmax and Km, depending on your data. The distribution factors on the Physiology tab are automatically loaded for recognized gut enzymes and transporters, and provide the relative amounts of enzymes or transporters in the various ACAT™ gut model compartments. The Vmax and Km scale factors on the Pharmacokinetics tab are provided to allow fitting nonlinear kinetic models to your data.
The Metabolism and Transporter Module includes a Units Converter tool for easy transformation of a variety of your in vitro metabolism or transporter kinetic parameters into values and units that can be utilized by the GastroPlus PBPK model.
Define multiple metabolic/transport pathways, with enzymes and transporters placed into the tissues or organs of your choice. Also, easily link the formation of different metabolites in a single simulation – no limit on the number of metabolites you want to track!