Metabolism & Transporter
What is the Metabolism and Transporter Module?
NEW! When linked with the upgraded ADMET Predictor™ Module, predict nonlinear pharmacokinetics for CYP metabolism, and have the Enzyme Table automatically populated with the correct locations and units!
Updated! Enzyme and transporter expression levels across species – including UGTs, SULTs, and transporters in various tissues in PBPK models!
Enhanced! Metabolite tracking options!
The Metabolism and Transporter Module is an optional module that extends the capabilities of GastroPlus™ to include nonlinear pharmacokinetics into any compartment (gut, liver, and/or any PBPK tissue), along with metabolite tracking. This module calculates Michaelis-Menten rates for gut and liver (or any PBPK tissue) metabolism and for carrier-mediated transport (influx or efflux – again, for any tissue in a PBPK model) based on input values for Vmax and Km.