Webinars

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Featured Webinars:

GastroPlus® v9.7 Release Webinar

Molecular Determinants of Cell Permeability Beyond the Rule of 5

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PKPlus™ 2.5 Release Webinar

Learn about the latest developments in PKPlus™

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GastroPlus® User Group Webinar: Applications/Experiences of PBPK Modeling to Support Regulatory Interactions

Recent experiences with PBPK model-based regulatory submissions used to obtain product development and DDI waivers will be discussed.

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Physiology Based Pharmacokinetic Modeling in Generic Drug Development and Regulatory Decisions- Opportunities & Challenges

Physiology based pharmacokinetic (PBPK) modeling is widely used within the pharmaceutical industry to predict oral drug absorption.

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GastroPlus® v9.7 Release Webinar

Learn about the latest developments in GastroPlus®!

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NAFLDsym v2A Release Webinar

NAFLDsym v2A includes mechanistic representation of fibrosis, steatosis, lipotoxicity, and inflammation. Over 1000 simulated patients with variability in their underlying pathophysiology, represent a spectrum of...

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ADMET Predictor® 9.5 Webinar

Significant enhancements have been made throughout both ADMET Predictor and MedChem Designer™.

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DILIsym® v8A Release Webinar

DILIsym is a mechanistic, predictive software tool focused on predicting and understand drug-induced liver injury across species. DILIsym version 8A is packed with exciting new features.

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Molecular Determinants of Cell Permeability Beyond the Rule of 5

Molecules that violate conventional guidelines for druglikeness—such as the Rule-of-5—are of increasing interest as chemical probes and drugs for intractable pharmacological targets.

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DDDPlus v6: In Vitro Dissolution… Reimagined

In vitro-in vivo extrapolation (IVIVE) has been a major focus of biopharmaceutics research over the last 20 years, and integration of in silico models built in GastroPlus™ help researchers identify in vitro methods for...

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Applying GastroPlus Modeling Establish Level A IVIVCs Waive Biostudies

Bioavailability/bioequivalence (BA/BE) evaluation by employing in vitro dissolution/release data and clinically relevant specification is required by the regulators. For BCS 1/BCS 3 drugs formulated as immediate release (IR) oral dosage forms, a BCS-based biowaiver may be granted based on the in vitro dissolution profiles generated across the physiologically relevant pH range. For drugs/formulations with dissolution/release limited/controlled absorption, establishing Level A in vitro – in vivo correlations (IVIVCs) can be applied and further utilized to assess whether BA/BE is recommended.

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