Featured Webinars:
MembranePlus™ v2 webinar: Stimulate your kinetic understanding…
Use of oral absorption modelling to characterize drug release and absorption of a BCS II compound from IR formulations
Watch Past Webinars
Applying MAM/PBPK Modeling to Predict Positive/Negative Food Effects: Approaches and Special Considerations
6.28.18 - It is widely recognized that food can affect the absorption of orally administered drugs. In the course of pharmaceutical development, food is evaluated clinically as part of the early single or multiple ascending dose studies; additional evaluations often take place when there are formulation changes. The outcome of these studies informs dosing instructions both during the conduct of clinical trials as well as on the product label.
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GastroPlus™ 9.6 Release Webinar: Improvements Supporting R&D Through Regulatory Interactions
4.24.18 - We are pleased to announce the release of GastroPlus™ 9.6! These improvements in our top-ranked PBPK modeling platform support discovery/preclinical/clinical R&D work through regulatory interactions.
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Discovery PBPK: How to enhance the expected accuracy of bioavailability predictions for NCEs that are not primarily metabolized
03.27.18 - In this webinar, we will review the accuracy of purely in silico estimates of bioavailability and the chemistry classification of new chemical entity (NCE) molecules that are easier or harder to accurately estimate using in silico or in vitro data. We will also introduce a novel Discovery PBPK method of local clearance modeling to enhance accuracy for bioavailability estimates for molecules that do not have metabolism as a primary mechanism of systemic clearance.
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What’s new in PKPlus™ version 2?
2.20.18 - In this webinar, we will demonstrate how PKPlus 2 combines functionality and flexibility for all PK analyses, providing the capabilities to meet the needs of scientists across departments at pharmaceutical companies, contract research organizations (CROs), and other non-pharma markets.
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Mechanistic In Vitro Dissolution PBPK Models to Drive Drug Development
11.30.17 - In this webinar, DDDPlus™, an in vitro simulation platform focused on providing predictive dissolution & precipitation tools for formulation development, will be presented in conjunction with GastroPlus™ to evaluate factors impacting in vivo performance of drug products.
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ADMET Predictor™ v8.5 Webinar – Discover ‘Discovery PBPK’: Efficiently use PBPK modeling to drive lead selection & optimization
11.9.17 - In this video, Michael Lawless discusses how to efficiently screen large compound libraries in minutes based on predicted in vivo fraction absorbed (Fa%) or oral bioavailability (F%) in virtual rats or humans, easily visualize how changes in structure will impact the predicted in vivo outcomes to optimize molecules and, by defining efficacious concentration estimates, determine target dose levels sooner to prioritize drug candidates.
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Understanding dermal drug disposition using TCAT™ – a novel PBPK model
9.14.17 - Scientists from GlaxoSmithKline and Simulations Plus have collaborated to develop a mathematical model, Transdermal Compartmental Absorption & Transit (TCAT™), that allows better understanding of drug penetration through the skin while accounting for the formulation characteristics, evaporation and precipitation effects that influence dermal delivery.
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