Upcoming Webinars
“Using PBPK modeling to assess the impact of diseases on oral drug absorption: a tale of 2 drugs”
Wednesday, June 29, 2022
5 AM CEST (Paris) / 8 AM PT (Los Angeles) / 11 AM ET (New York)
Randomized clinical trial is the most effective way to determine whether a cause-and-effect relationship exists between an intervention and a predefined clinical outcome. Much attention has been paid to the internal validity of a clinical trial, i.e. the extent to which the design and conduct of a trial eliminates the possibility of bias. In this webinar, we will go over two case studies leveraging IVIVE-PBPK modeling to prospect the impact of HIV and cystic fibrosis on the oral absorption of two broadly prescribed BCS 2 drugs.
Presenter:
Dr. Rodrigo Cristofoletti
Assistant Professor, Center for Pharmacometrics & Systems Pharmacology, Dept. of Pharmaceutics
University of Florida
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“Predicting pharmacokinetics of multisource acyclovir oral products through Physiologically Based Biopharmaceutics Modeling”
Wednesday, July 13, 2022
5 AM CEST (Paris) / 8 AM PT (Los Angeles) / 11 AM ET (New York)
Highly variable disposition after oral ingestion of acyclovir has been reported, although little is known regarding the underlying mechanisms. Different studies using the same reference product (Zovirax ®) showed that Cmax and AUC were respectively 44 and 35% lower in Saudi Arabians than Europeans, consistent with higher frequencies of reduced-activity polymorphs of the organic cation transporter (OCT1) in Europeans. This webinar will explore this study in depth.
Presenters:
Dr. Peter Langguth, University Professor at Johannes Gutenberg University Mainz
Dr. Mauricio A. Garcia, PhD student/Research Assistant, Johannes Gutenberg University Mainz
Register Here
Watch Past Webinars
ADMET Predictor™ 7.0 Release
Learn about all the new features in ADMET Predictor 7.0 and how they can help you.
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Bayer pKa Collaboration Webinar
In this webinar, we present a new in silico multiprotic pKa prediction tool with upgraded functionality, improved prediction accuracy and significantly expanded applicability domain.
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In vivo Dissolution and Precipitation
This webinar, hosted by the GastroPlus User Group, focuses on the simulation of in vivo dissolution and precipitation based on in vitro experimental data using GastroPlus, with the goal to provide better predictive oral absorption kinetics.
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What’s New in GastroPlus™ 8.5?
This webinar walks you through the new features and enhancements in GastroPlus version 8.5. Among the topics that will be covered: - new mechanistic model for in vivo precipitation kinetics...
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Lead hopping and de novo design webinar
This webinar discusses details of lead hopping and de novo design with MedChem Studio™, and demonstrates the software's ability to generate new virtual structures quickly and easily.
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Physicochemical and biopharmaceutical properties
This webinar describes our modeling methodology and highlights the performance of key models. Special attention is devoted to our novel method of predicting macroscopic pKa, and our "Absorption Risk" Score.
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In Silico Metabolism Webinar
The Metabolism Module in ADMET Predictor™ contains in silico models that classify compounds as substrates and/or inhibitors of the major CYP isoforms, while also predicting likely sites of metabolism and...
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Matched Molecular Pairs Webinar
This webinar describes algorithms for the rapid and automatic extraction of Matched Molecular Pairs (MMPs) from large chemical data sets and for converting these pairs into structural transformation rules that...
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Toxicity Webinar
Simulations Plus offers a rapidly growing array of accurate predictive models in ADMET Predictor™, focused on toxicity endpoints deemed important by regulatory agencies.
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ADMET Design Suite™ Webinar
This webinar provides an introduction to an in silico lead optimization process that begins with high throughput screening data via class generation, R-group analysis, scaffold hopping, activity cliff detection...
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