What is IVIVCPlus™?
IVIVCPlus is an optional add-on module that provides a convenient way to develop a correlation (IVIVC) between either in vitro release and in vivo release or in vitro release and absolute bioavailability. The formed correlation can then be used to either predict plasma concentration-time profiles for formulations with different in vitro release rates or, potentially, for biowaiver purposes.
GastroPlus was the first software program to offer “mechanistic deconvolutions”, which deconvolute, or fit, the in vivo dissolution vs. time along the gut lumen. An advantage to using the mechanistic deconvolution method is that it can be linked to a PBPK model (through the PBPKPlus Module). We are pleased to validate the mechanistic deconvolution method through a 5-year Research Collaboration Agreement with the U.S. FDA.