GastroPlus™

PBPK modeling software – from discovery through
development…

Choose a Module:

PKPlus™

What is PKPlus™?

PKPlus extends GastroPlus™ to rapidly estimate pharmacokinetic (PK) parameters for noncompartmental analysis (NCA), along with 1-, 2-, & 3-compartment PK models from pharmacokinetic studies (IV and/or oral) without the need to run full simulations. The optimization and selection of the appropriate compartmental PK model is automated from a single mouse click, but you control which parameters are transferred back to the main GastroPlus model.

The fitted parameters include PK parameters, first order absorption rate, bioavailability and absorption lag time (if both IV and oral data are included in fitting). Required inputs are plasma concentration-time profiles, dose, body weight and infusion time (if applicable). Compartmental PK models can be fitted to single IV or oral data as well as across multiple plasma concentration-time profiles – IV, oral, or combination of IV and oral as well as different dose levels. Linear or saturable clearance models can be selected easily.

Full statistics, including Akaike Information Criterion and R^2, are provided for all models. Residual information is also captured and can be plotted. Once finished in PKPlus, the parameter values of the selected model can be easily transferred back to the main GastroPlus model, and report-quality outputs can be captured and saved.

In the figures provided you will see:

  • Plotting of absolute, log, and residuals for each model is selected with a mouse click, allowing rapid comparison of models.
  • 2-compartment PK model for midazolam fitted across IV and three oral doses.
  • Residuals plot for 2-compartment PK model for midazolam fitted across IV and three oral doses.