ACoP13 – American Conference of Pharmacometrics
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  • Aurora, CO
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American Conference of Pharmacometrics – “Together Moving Mountains”

Join Simulations Plus for the following workshops:

October 29, 2022
8:00 am – 5:00 pm MDT

Title: Introductory Course on Pharmacometric Modeling with Monolix™
Main instructor: Amparo de la Peña
Secondary instructor: Monika Twarogowska

If you want to start using Monolix for your popPK/PD modeling, or you have already started and want to become a more confident user, then this course is for you. We will teach you all you need to know to develop, diagnose and interpret population models for your PK/PD datasets. After a reminder of the key concepts of the population approach, we will show you how to format your dataset, do a first exploratory data visualization, set up a model in the Monolix GUI and analyze the run results. Modeling workflows and strategies will also be discussed.

Better understanding and confidence comes from practice. You will improve it during an interactive and guided hands-on session on a typical PK/PD dataset – an opportunity to immediately apply new skills with the help from the Lixoft team.

Temporary licenses for the MonolixSuite will be provided.

October 30, 2022
8:00 am – 5:00 pm MDT

Title: Advanced course on Pharmacometrics modeling with Monolix™
Main Instructor: Pauline Traynard
Secondary instructor: Monika Twarogowska

This training is designed for modelers with already some experience of Monolix, who wish to i) better understand the algorithms and their options, ii) learn how to implement complex models, iii) improve their strategy for model building.

The course will alternate lectures and interactive hands-on sessions with Monolix.

I – Algorithms and good practices for parameter estimation

  • Estimating the population parameters: theory and practice
    • SAEM and its settings
    • Assessing the convergence
    • Handling parameters without variability
    • Bayesian estimation of population parameters
  • Settings of MCMC: transition kernels, automatic stopping rule
  • Estimating the Fisher Information Matrix with linearization or stochastic approximation
  • Estimating the likelihood with linearization or importance sampling Monte Carlo

II – Methods for statistical model building

  • Diagnostics for the statistical model
    • Interpretation of diagnostic plots
    • Performing unbiased statistical tests
    • Defining and using the shrinkage correctly
  • Strategies for automatic model building
    • Covariate search using COSSAC
    • Model building using SAMBA

III – Implementing complex PKPD models

  • Modeling non-continuous data
  • Sequential and simultaneous approaches for joint models
  • Complex statistical models
    • Non-standard inter-individual variability
    • Inter-occasion variability
    • Complex covariate-parameter relationships

To register for these workshops use the ACoP13 registration form.  

 

PRESENTATIONS: 

Title: Development of a Physiologically Based Pharmacokinetic (PBPK) Model for Pexidartinib to Evaluate the Impact of Meal Contents and Intake Timing on Drug Exposure (Abstract PBPK426)
Poster presented by: Daiichi (Simulations Plus coauthors: Jim Mullin, Sandra Suarez-Sharp, Viera Lukacova)

Title: A Physiologically Based Pharmacokinetic Model of Long-Acting Lenacapavir (Abstract PBPK374)
Poster presented by: Gilead (Simulations Plus coauthor: Viera Lukacova)