• - Past
  • Seattle, WA

24th International Symposium on Microsomes and Drug Oxidations (MDO) and 13th International Meeting of the International Society for the Study of Xenobiotics (ISSX).

Diversity in DMPK: The Science and the Scientists”


Author: Chief Scientific Officer, Viera Lukacova
Title: Absorption Predictions: Current Capabilities and Knowing the Gaps
Description: For orally administered drug products, the rate and the extent of drug absorption are results of complex interplay between different processes affecting the formulation and the drug itself. These processes include dissolution, precipitation, passive paracellular and transcellular permeability, and carrier-mediated uptake and efflux. For accurate absorption predictions, the models need to capture these processes, their interplay, and also their regional differences caused by changing physiology along the gastrointestinal tract. This presentation will discuss the role of physiologically based modeling in absorption predictions. Examples will be used to demonstrate the influence of different processes on the predicted intestinal drug absorption.
Date/Time: Sunday, September 11 from 1:05 – 1:45 pm PT
Location: Cascade Ballroom I, The Westin Seattle


Presenter: Senior Scientist, Tarang Vora 
Title: Physiologically based Pharmacokinetic (PBPK) modeling of Pyrotinib to understand the impact of interplay between CYP3A4 and P-GP in its DDI’s with CYP3A4 inhibitors/inducers.
Poster #: P55
Date/Time: Poster Session 1, Tuesday, September 13, 12:30 – 1:30 pm PT
Location: Fifth Avenue Room, The Westin Seattle

Presenter: Scientist II, Revathi Chapa
Title: Delineating the complex interplay of enzymes and transporters in governing the absorption and disposition of Atorvastatin and the metabolites using physiologically based pharmacokinetic (PBPK) modeling.
Poster #:  P153
Date/Time: Poster Session 2, Wednesday, September 14, 12:30 – 1:30 pm PT
Location: Fifth Avenue Room, The Westin Seattle

Presenter: Postdoc Research Associate, UNC, Jeffry Adiwidjaja
Co-authors:  Senior Scientist II, Jessica Spires and Associate Dean, UNC, Kim LR Brouwer
Title: Implementation of a Physiologically Based Pharmacokinetic Modeling Approach to Predict Disease-Related Changes in Drug Pharmacokinetics in Patients with Nonalcoholic Fatty Liver Disease
Poster #: A12
Date/Time: Monday, September 12, 1:30 – 2:15 pm PT
Location: Fifth Avenue Room, The Westin Seattle


Come visit with Executive Director, Simulations Studies, Grace Fraczkiewicz and Director of Business Development Dan O’Connor in our booth (#30).