Contributing Factors To Serious Adverse Outcomes

Contributing Factors To Serious Adverse Outcomes

Authors: Bacon D, Skomra R, Walawander CA, Knight P
Conference: IARS
Keywords: accreditation, adverse effects, anesthesia, anesthesiology, benchmark, central nervous system agents, chi square, geriatrics, hospital, JCAHO, Joint Commission, monitoring, morbidity, mortality, performance, perioperative, risk, safety, standards, surgery, Wilcoxon
Division: Clinical Pharmacology and Pharmacometrics (CPP)

JCAHO is an accrediting body for hospitals in the United States. As part of the accreditation process, the JCAHO is initiating a new program called ORYX. The goal of the program is to integrate routinely…

Efficacy Of Bupropion Sr On Reducing Craving In Smoking Cessation

Efficacy Of Bupropion Sr On Reducing Craving In Smoking Cessation

Authors: Fiedler-Kelly J, Grasela TH, Glover ED, Sachs DPL, Johnston JA
Conference: CINP Congress
Keywords: adult, cessation, cigarettes, Emax, Fagerstrom, logit transform, nictotine, NONMEM, patch, predicted odds, proportional-odds model, psychotherapeutic agents, rating, time course
Division: Clinical Pharmacology and Pharmacometrics (CPP)

Bupropion HCl sustained release (Bup SR, ZybanTM) is the first non-nicotine treatment proven to be safe and effective for smoking cessation. Clinical studies have demonstrated that when used in…

Implementation of concentration dependent “first-pass” models using NONMEM

Implementation of concentration dependent “first-pass” models using NONMEM

Authors: Phillips L, Cox SR
Conference: AAPS
Keywords: bioavailability, concentration dependent, control stream, depot, first-pass, Michaelis-Menten, nonlinear, NONMEM, P450, PKPD methodology, simulation, steady state
Division: Clinical Pharmacology and Pharmacometrics (CPP)

The development of drugs extensively metabolized by the P450 enzyme system may require the need to model concentration dependent 'first-pass' effects. This simulation study, performed using NONMEM…