Modeling of Active Transport and Metabolism for in vitro Suspended and Sandwich Hepatocyte Assays Utilizing MembranePlus

Authors: Mullin JM
Conference: MEEX
Keywords: in vitro, metabolism, sandwich hepatocyte assays
Software: ADMET Predictor®, GastroPlus®, MembranePlus™
Division: PBPK

Overview

• MembranePlus™ – a software platform for simulaton of drug transport in cell assays.
• Development of Hepatocyte Transport Model
– Sandwich and plated hepatocytes.
– Suspended hepatocytes.
• Model Case Studies
– Sodium Taurocholate transport
– Sta1ns (uptake+metabolism)
– IVIVE with combina1on of MembranePlus and GastroPlus

SOLVO Meet the Experts Transporters Conference, April 10-12, 2017, San Francisco, CA

By James Mullin