Modeling of Active Transport and Metabolism for in vitro Suspended and Sandwich Hepatocyte Assays Utilizing MembranePlus
• MembranePlus™ – a software platform for simulaton of drug transport in cell assays.
• Development of Hepatocyte Transport Model
– Sandwich and plated hepatocytes.
– Suspended hepatocytes.
• Model Case Studies
– Sodium Taurocholate transport
– Sta1ns (uptake+metabolism)
– IVIVE with combina1on of MembranePlus and GastroPlus
SOLVO Meet the Experts Transporters Conference, April 10-12, 2017, San Francisco, CA
By James Mullin