DILIsym®

Quantitative systems toxicology (QST) software
for drug-induced liver injury (DILI)

Click here for an overview presentation on DILIsym

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DILIsym Services and Cyprotex, an Evotec Company, have teamed up to enhance the quality of your toxicology predictions!

Cyprotex provides high quality in vitro data and expertise to support DILIsym software representations of mitochondrial dysfunction, oxidative stress, and lipotoxicity via the following endpoints:

  • Mitochondrial function assay with the Agilent Seahorse XF Analyzer providing outputs such as oxygen consumption rate (OCR) and extracellular acidification rate (ECAR)
  • Cell health parameters from high content imaging assessments with markers such as oxidative stress or reactive oxygen species (ROS), glutathione (GSH), mitochondrial membrane potential, ATP and steatosis
  • Mass spectrometry services to assess intracellular concentrations for each assay

DILIsym simulation results also help with selection of future in vitro assays to be completed, making the data collection / simulation cycle iterative.

Team up with DILIsym and Cyprotex today and get more information out of your data! Visit Cyprotex here to get more information on their services directly, or engage them indirectly with DILIsym Services serving as your white glove, “one stop shop” project manager.

Download a poster here showing use of Cyprotex data for DILIsym predictions.