dsBiologics
What is the Biologics Module?
We are pleased to offer PBPK models for large molecules (biologics). The Biologics Module simulates the systemic absorption and pharmacokinetics of biologics – for both monoclonal antibodies (mAb) and NEW! antibody-drug conjugates (ADCs). In the current implementation, both mAbs and ADCs administered as an intravenous bolus dose, intravenous infusion, subcutaneous (SQ), and NEW! intramuscular (IM) injections (both bolus and controlled release) can be modeled.
As with other GastroPlus modules, there is no equation or code writing required. A schematic diagram of how the different organs are connected to one another is shown below. All major organs are connected in an anatomical fashion with plasma flow represented by blue solid arrows and lymph flow by red dashed arrows.
The lymph node collects the lymphatic drainage from organs and lymph fluid is returned to the systemic circulation. Each organ in the PBPK model is divided into three major compartments representing the vascular, endosomal, and interstitial spaces.
Resources
Application of PBPK Modeling to Predict Monoclonal Antibody Disposition after Intravenous and Subcutaneous Administration in Rats and Humans
Learn MoreTherapeutic monoclonal antibodies (mAbs) represent a growing segment of the development pipeline in the pharmaceutical industry. Physiologically based pharmacokinetic (PBPK) modeling has been extensively...
Development of Physiologically Based Pharmacokinetic (PBPK) Model for Simulating the Disposition of Antibody Drug Conjugates
Learn MoreAntibody- drug conjugates (ADCs) are a novel class of therapeutic agents that deliver potentcy totoxic drug molecules (payload) to their targets while reducing systemic exposure. ADCs may be composed of...