High-Fat Breakfast Increases Bioavailability of Albendazole Compared to Low-Fat Breakfast: Single-Dose Study in Healthy Subjects

High-Fat Breakfast Increases Bioavailability of Albendazole Compared to Low-Fat Breakfast: Single-Dose Study in Healthy Subjects

Publication: Front Pharmacol

Albendazole is a benzimidazole carbamate drug with anthelmintic and antiprotozoal activity against intestinal and tissue parasites. It has been described that the administration with meals increases albendazole absorption.

A novel in silico method to predict drug PK profile in human and its application to build the PBPK model of Hydroxychloroquine for COVID-19 treatment

A novel in silico method to predict drug PK profile in human and its application to build the PBPK model of Hydroxychloroquine for COVID-19 treatment

Authors: Zhai J
Publication: Univ Pittsburgh

The first part of this study is to develop a novel protocol to predict the pharmacokinetic profiles of a target drug based on the Physiologically based pharmacokinetic (PBPK) model of a structurally similar template drug by combining predictions from two software for PBPK modeling, the SimCYP simulator and ADMET Predictor.

Development of an In Vivo Predictive Dissolution Methodology of Topiroxostat Immediate-Release Tablet Using In Silico Simulation

Development of an In Vivo Predictive Dissolution Methodology of Topiroxostat Immediate-Release Tablet Using In Silico Simulation

Publication: AAPS PharmSciTech
Software: GastroPlus®

The main objective of this study was to develop an in vivo predictive dissolution (IVPD) model for topiroxostat immediate-release (IR) formulation...

Concentration-QTc Analysis of Quizartinib in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Concentration-QTc Analysis of Quizartinib in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Publication: Cancer Chemother Pharmacol

This analysis evaluated the relationship between concentrations of quizartinib and its active metabolite AC886 and QT interval corrected using Fridericia's formula (QTcF) in patients with...

Molecular modeling for potential cathepsin L inhibitor identification as new anti-photoaging agents from tropical medicinal plants

Molecular modeling for potential cathepsin L inhibitor identification as new anti-photoaging agents from tropical medicinal plants

Publication: J Bioenerg Biomemb
Software: ADMET Predictor®

Ultraviolet exposure can cause photoaging toward the human skin which is begun by the inflammation on the exposure area, also resulting in activation of a degradative enzyme cathepsin L.

Prediction of fraction unbound in plasma in children in data-limited scenarios for human health risk assessment

Prediction of fraction unbound in plasma in children in data-limited scenarios for human health risk assessment

Authors: Yun YE, Edginton AN
Publication: Computational Toxicology
Software: ADMET Predictor®

In human health risk assessment, pediatric physiologically-based pharmacokinetic modeling has been used to predict chemical-specific toxicokinetic adjustment factors.

Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin

Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin

Publication: AAPS PharmSciTech
Software: GastroPlus®

We focused to explore a suitable solvent for rifampicin (RIF) recommended for subcutaneous (sub-Q) delivery [ethylene glycol (EG), propylene glycol...

Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension

Extemporaneous Compounding and Physiological Modeling of Amlodipine/Valsartan Suspension

Publication: Int J Hypertension
Software: GastroPlus®
Division: PBPK

In case of absent liquid dosage form, crushing a tablet or dispersing a capsule would be the most convenient option for using these drugs in patients with dysphagia difficulties.

In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives

In vitro and in vivo correlation for lipid-based formulations: Current status and future perspectives

Authors: Huang Y, Yu Q, Chen Z, Wu W, Zhu Q, Lu Y
Publication: Acta Pharm Sin B
Software: GastroPlus®
Division: PBPK

Lipid-based formulations (LBFs) have demonstrated a great potential in enhancing the oral absorption of poorly water-soluble drugs.

A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

Publication: Acta Pharm Sin B
Software: GastroPlus®
Division: PBPK

Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.

A Survey of the Regulatory Requirements for the Waiver of In Vivo Bioequivalence Studies of Generic Products in Certain Dosage Forms by Participating Regulators and Organisations of the International Pharmaceutical Regulators Programme

A Survey of the Regulatory Requirements for the Waiver of In Vivo Bioequivalence Studies of Generic Products in Certain Dosage Forms by Participating Regulators and Organisations of the International Pharmaceutical Regulators Programme

Publication: J Pharm Pharm Sci
Division: PBPK

The requirements to waive in vivo bioequivalence studies for immediate release solid oral dosage forms based on the Biopharmaceutics Classifications System (BCS) are well known, and biowaivers[1] for other types of oral dosage forms based on pre-defined criteria may also be acceptable.

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Dogs

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Dogs

Publication: Mol Pharm
Software: GastroPlus®
Division: PBPK

Colon absorption is a key determinant for the successful development of modified-release (MR) formulations, and the risk that colon absorption may limit the in vivo performance...