Machine learning and artificial intelligence (ML/AI) have become important research tools in molecular medicine and chemistry.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Anti‐CD38 Cytolytic Antibody TAK‐079 in Healthy Subjects
This investigation characterised tolerability, pharmacokinetics and pharmacodynamics of the
Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D3 and Its Natural Derivatives
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements.
Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D 3 and Its Natural Derivatives
Vitamin D3 is an endogenous fat-soluble secosteroid, either biosynthesized in human skin or absorbed from diet and health supplements.
Synthesis and Characterization of 9-(4-[18F]Fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine as a Novel PET Agent for Mutant Herpes Simplex Virus Type 1 Thymidine Kinase Reporter Gene Imaging
[18F]FHBG has been used as a positron emission tomography (PET) imaging tracer for the monitoring of herpes simplex virus type 1 thymidine kinase...
Teaching of Biopharmaceutics in a Drug Design Course: Use of GastroPlus as Educational Software
Drug design and development requires collaboration among scientists with diverse expertise.
Modeling of ayurveda ghee based solid lipid nano particles and their comprehensive pharmacokinetics study
Several experiments have been done with solid lipid nanoparticles (SLNPs) module to produce a potential oral drug delivery system.
Food Effects on Oral Drug Absorption: Application of Physiologically-Based Pharmacokinetic Modeling as a Predictive Tool
The bioavailability of an orally administered small molecule is often dictated by drug-specific...
Holistic Prediction of the pKa in Diverse Solvents Based on a Machine‐Learning Approach
While many approaches to predict aqueous pKa values exist, the fast and accurate prediction of non‐aqueous pKa values is still challenging.
Pentabromobenzyl-RP versus triazole-HILIC columns for separation of the polar basic analytes famotidine and famotidone: LC method development combined with in silico tools to follow the potential consequences of famotidine gastric instability
The competence of hydrophilic interaction (HILIC) and reversed phase liquid chromatography (RPLC) modes, employing two new stationary phases...
Global testing of a consensus solubility assessment to enhance robustness of the WHO biopharmaceutical classification system
The WHO Biopharmaceutical Classification System (BCS) is a practical tool to identify active pharmaceutical ingredients (APIs) that scientifically qualify for...
Review of the pharmacokinetics and metabolism of triclopyr herbicide in mammals: Impact on safety assessments
A review of pharmacokinetic and metabolism studies show that triclopyr is well absorbed from the oral route in numerous species...
The art of atom descriptor design
This review provides an overview of descriptions of atoms applied to the understanding of phenomena like chemical reactivity and selectivity...
Estimation of Attainment of Steady‐State Conditions for Compounds With a Long Half‐Life
Half‐life is a standard result reported with analysis of pharmacokinetic data.
Phytocannabinoid drug-drug interactions and their clinical implications
Cannabis is a plant with a long history of human pharmacological use, both for recreational purposes and as a medicinal remedy.
Policy of Multisource Drug Products in Latin America: Opportunities and Challenges on the Application of Bioequivalence In Vitro Assays
Background: The replacement of traditional in vivo bioequivalence studies by in vitro dissolution assays, based on the biopharmaceutical classification system (BCS), has...
Biopharmaceutical characterization of rebamipide: The role of mucus binding in regional-dependent intestinal permeability
In this study, we aimed to elucidate biopharmaceutical characteristics of the anti-ulcer drug rebamipide, with special emphasis on the...
Computational Methods Used in Phytocompound-Based Drug Discovery
Phytocompounds are gaining popularity, due to lesser toxicity, greater bioavailability and high chemodiversity.
In silico models for genotoxicity and drug regulation
Whereas in the past, (Q)SAR methods have been largely used to support the design of new drugs, in the last few decades...
Application of synthetic membranes in establishing bio-predictive IVPT for testosterone transdermal gel
The current study investigated the use of synthetic membranes in developing a bio-predictive in vitro permeation testing (IVPT) method for 1.62% testosterone gel.