Design, Synthesis, and Neuroprotective Activity of Phenoxyindole Derivatives on Antiamyloid Beta (Aβ) Aggregation, Antiacetylcholinesterase, and Antioxidant Activities

Design, Synthesis, and Neuroprotective Activity of Phenoxyindole Derivatives on Antiamyloid Beta (Aβ) Aggregation, Antiacetylcholinesterase, and Antioxidant Activities

Authors: Laivut S, Moongkarndi P, Kitphati W, Rukthong P, Sathirakul K, Sripha K
Publication: Pharmaceuticals
Keywords: alzheimer's disease, Antiamyloid beta aggregation, antioxidant, indole-based scaffold, neuroprotective activity
Software: ADMET Predictor®
Therapeutic Areas: CNS

In this investigation, a number of phenoxyindole derivatives were designed, synthesized, and tested for their neuroprotective ability on SK-N-SH cells against ...

Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium “Long-Acting Injectables” Working Group

Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium “Long-Acting Injectables” Working Group

Authors: Bauer A, Berben P, Chakravarthi SS, Chattorraj S, Garg A, Gourdon B, Heimbach T, Huang Y, Morrison C, Mundhra D, Palaparthy R, Saha P, Siemons M, Shaik NA, Shi Y, Shum S, Thakral NK, Urva S, Vargo R, Koganti VR, Barrett SE
Publication: Pharm Res
Keywords: biopharmaceutics, gastroplus, intramuscular injection, lai, pbbm, PBPK modeling, physiologically based pharmacokinetics, subcutaneous injection
Software: GastroPlus®

Long-acting injectable (LAI) formulations can provide several advantages over the more traditional oral formulation as drug product opportunities. LAI formulations...

Assessment of food effects during clinical development

Assessment of food effects during clinical development

Authors: Vinarov Z, Butler J, Kesisoglou F, Koziolek M, Augustijns P
Publication: Int J Pharm
Keywords: biopharmaceutics, fed state, food-drug interaction, gastroplus, pbbm, PBPK modeling, physiologically based pharmacokinetics
Software: GastroPlus®

Food-drug interactions frequently hamper oral drug development due to various physicochemical, physiological and formulation-dependent mechanisms.

Real World Impact + Regulatory Decision Making Track: All-Presenter Panel Discussion

Real World Impact + Regulatory Decision Making Track: All-Presenter Panel Discussion

Authors: Chauvin J, Pepin X, Le Merdy M, Novaes Borges L, Del Frari L, Ahmed T, Martins F
Keywords: MIDD (model-informed drug development), MIDD+ 2023, modeling and simulation, SLP MIDD+ Virtual Conference, SLP2023MIDD
Division: PBPK

Session panelists include: Jonathan Chauvin, Xavier Pepin, Maxime Le Merdy, Luiza Novaes Borges, Laurence Del Frari, Tausif Ahmed, and Frederico Martins.

Real World Impact + Regulatory Decision Making Track Poster Presentation: Building of Encorafenib Physiologically Based Pharmacokinetic Model and its Qualification to Predict Drug Drug Interaction with Posaconazole

Real World Impact + Regulatory Decision Making Track Poster Presentation: Building of Encorafenib Physiologically Based Pharmacokinetic Model and its Qualification to Predict Drug Drug Interaction with Posaconazole

Authors: Del Frari L, Lukacova V, Reddy M
Keywords: MIDD (model-informed drug development), MIDD+ 2023, modeling and simulation, SLP MIDD+ Virtual Conference, SLP2023MIDD

Presented by Laurence Del Frari, Pierre Fabre at MIDD+ 2023 on Thursday, February 16th.

Real World Impact + Regulatory Decision Making Track: GastroPlus® Simulations to Monolix™ for Trial Design

Real World Impact + Regulatory Decision Making Track: GastroPlus® Simulations to Monolix™ for Trial Design

Authors: Chauvin J, Le Merdy M
Keywords: Lixoft, MIDD (model-informed drug development), MIDD+ 2023, modeling and simulation, SLP MIDD+ Virtual Conference, SLP2023MIDD
Software: GastroPlus®, Monolix®
Division: Clinical Pharmacology and Pharmacometrics (CPP), PBPK

Presented by Jonathan Chauvin and Maxime Le Merdy at MIDD+ 2023 on Thursday, February 16th.

Women in Pharmaceutical Science Roundtable: “Strategies for Moving the Needle on Gender Equity”

Women in Pharmaceutical Science Roundtable: “Strategies for Moving the Needle on Gender Equity”

Authors: Fiedler-Kelly J, Twarogowska M, Do Dela A, Padron A, Luke L, Yang K, Voelkner N, Fohey J, Musser B, Le Merdy M, Siler SQ
Keywords: Lixoft, MIDD (model-informed drug development), MIDD+ 2023, modeling and simulation, SLP MIDD+ Virtual Conference, SLP2023MIDD, women in science
Division: Clinical Pharmacology and Pharmacometrics (CPP), PBPK, Quantitative Systems Pharmacology (QSP)

Session panelists include: Jill Fiedler-Kelly, Monika Twarogowska, An Do Dela, Arlene Padron, Lindsay Luke, Kyunghee Yang, Nivea Voelkner, Josh Fohey, Brian Musser...