What is QST/QSP Modeling?

Authors: Siler SQ
Software: DILIsym®, NAFLDsym®

Chief Science Officer of DILIsym Services, Scott Q. Siler, with more than 20 years of developing and utilizing QST and QSP modeling to help ensure treatments are both safe and effective answers it simply, “think of modeling like photography.”

While, the origin of systems toxicology lies in studying the cumulative effects of various environmental exposures on human health, there has been a tremendous increase in the application of this approach in the field of medicine. Quantitative systems pharmacology (QSP) has been defined as, “an approach to translational medicine that combines computational and experimental methods to elucidate, validate, and apply new pharmacological concepts to the development and use of small molecule and biologic drugs.” (https://www.sciencedirect.com/science/article/pii/S2468202017300700)

How does this relate to photography?

Let’s think of the photography’s 3 basic components: a camera, a photograph, and a picture frame.

  • The outcome of QST and QSP modeling is essentially to inform and accelerate a clinical development program, very much like a photograph depicts 1,000 words.
  • A photograph can be generated with a variety of camera types. In this scenario, the camera type is the model type.
  • The communication of simulation results is the photograph and with the proper framing, that supports project team decisions and regulatory communications, we can make the photograph (modeling results) more impactful.

At Simulations Plus we’ve developed great cameras (model types) but we emphasize the photograph (modeling results.)

Let us help you visualize the future with our modeling and simulations services by filling out the Contact Us form. Learn more here: https://www.simulations-plus.com/services/pharmaceutical/qsp-modeling-of-nafld-nash/