Software Installation

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Software Installation

Our software is designed to run on Pentium-class Windows 8 (64-bit) and Windows 10 (64-bit) computers or Windows Server 2012 and 2012 R2 (64-bit), Windows Server 2016 (64-bit), and Windows Server 2019 (64-bit). A minimum of 1 GB of RAM is recommended for optimal performance.

Most modern Pentium machines with speeds of 1 GHz or faster should be able to run our software; however, simulation software is computationally intensive and always benefits from greater speed and memory. On a 2.4 GHz Pentium 4 computer with 512 MB of RAM, our software executes a typical 24-hour single simulation in less than one second with standard compartmental pharmacokinetics. Because they incorporate a much larger set of differential equations, PBPK simulations typically require about 5-10 seconds, but can be longer.

Our software runs on Mac operating systems with Windows virtualization.

Flexera License Server

Supported operating systems and processors.

Cloud Service Offerings

All Simulations Plus Inc. software can be deployed via a cloud based model using Amazon Web Services (EC2), a scalable, reliable, and secure global computing infrastructure, that is the virtual backbone of’s multi-billion dollar online business that has been honed for over a decade.

You pay only for the software licenses, plus compute power, storage, and other resources you use, with no long-term contracts or up-front commitments.

Using our cloud model, our customers don’t have to worry about installation deployment, upgrades, licensing, or administration of computing resources, as our dedicated cloud specialists take care of all information technology related tasks, so that our customers can focus on science.

KIWI Requirements

Software: Internet Explorer 10+, Mozilla Firefox 10+, and Google Chrome 17+ with JavaScript-enabled in browser* and Adobe Acrobat Reader installed.

*Several JavaScript components require that the Internet Browser sends a valid user agent string. If a custom user agent string is necessary for your browser, it should be appended to the default string and not replace it.

Note: KIWI can export results in .docx and .xlsx format, which requires Microsoft Office version 2003 or later to be open.

Hardware: 1GB RAM or greater. Screen size of 22″-24″ widescreen (16:10 aspect ratio)*

*Though any screen size above 19″ can be used, KIWI has been designed to fully utilize a large, wide screen for greater user efficiency. This is especially true for the KIWI Summarize module.


Each user license can be installed on a standalone machine (‘standalone’) or uploaded to a network server (‘floating seat’) – there is no difference in price, as we charge one license fee for our products. It is left to your organization as to how the license(s) will be made available to the user community.

As you can imagine, the vast majority of our clients will install the software to a network license server (or similar shared resource), as the sharing of licenses between users & across departments provides significant value for companies of all sizes. The restriction is that the user license is only to be accessed by those scientists based within a specific geographical location (within fifty (50) miles of the territorial boundaries of the city where the software is installed).

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