In this video, we demonstrate how to open chemical structure files and import external property data. You will also see how to save progress using proprietary XDK session files.
Integrating Diverse Clinical Data into a Single Virtual Population with Thales™
As the complexity of drug development increases, researchers need quantitative systems pharmacology (QSP) models that incorporate virtual populations and can capture data spanning numerous clinical trial
Simulations Plus Convenes Industry and Regulatory Leaders to Define Responsible AI in MIDD
Expert panel at the 2026 ASCPT Annual Meeting brings together leaders with industry and regulatory experience to explore practical, accountable AI implementation
Development of a Quantitative Systems Toxicology Model to Predict Drug-Induced Liver Injury in Pediatrics
Drug-induced liver injury (DILI) is an underrecognized cause of pediatric liver disease which accounts for almost 20% of pediatric acute liver failure cases, and is a major reason for liver transplantation in the USA [1].
Prospective Physiologically Based Pharmacokinetic Modeling Predictions of First-in-Patient Study PK: Examples and Application
The examples shown here are intended to provide an update on the accuracy of the method for prospective predictions.
A Pediatric Pbpk Model of Atropine Gel To Predict Atropine Levels in Children With Neurological Disorders After Administration to Oral Cavity
Sialorrhea, or excessive salivation, is a chronic and serious problem in children with cerebral palsy (CP) and neurodevelopmental disorders.[1–5] Sialorrhea occurs in up to 60% of children with CP...
Automated Concentration-QT data preparation, model selection and reporting in R
Since the publication of the ICH E14 guidance in 2015, QT interval prolongation as-sessment can be carried out with a concentration-QTc modeling approach as part of single- or mul-tiple- dose escalation studies, instead of conducting a thorough QT/QTc study.
mlxDesignEval: A novel R package for design evaluation based on MonolixSuite, and its comparison to popED and PFIM
Designing clinical trials to support population PK/PD modeling requires careful choices of sampling times, number of subjects, dose groups and other trial features to
ensure precise parameter estimation - with low relative standard errors [1].
Developing Biosimilars: How to Design PK and PD Similarity Studies Using Modeling & Simulation
Biosimilar development is crucial to making lifesaving treatments more affordable and accessible to patients—and researchers are under increasing pressure to reduce cost and time without compromising scientific rigor
GPX™ Tutorial Series: Introduction to Reprise Licensing
In this video we'll be talking about Introduction to Reprise Licensing.
GPX™ Tutorial Series: Injectables Intramuscular
In this video we'll be talking about Injectables Intramuscular.
GPX™ Tutorial Series: Injectables Subcutaneous
In this video we'll be talking about Injectables Subcutaneous.
GPX™ Tutorial Series: AssessmentsPlus
In this video we'll be talking about AssessmentsPlus.
GPX™ Tutorial Series: P-PSD
In this video we'll be talking about P-PSD.
GPX™ Tutorial Series: Orchestrator
In this video we'll be talking about Orchestrator.
GPX™ Tutorial Series: ACATPlus
In this video we'll be talking about GPX ACATPlus.
Pharmacokinetic Studies and Synergistic Antitumor Effects of Cannabichromene and Cannabidiol in Drug-Resistant Breast Cancers
Triple-negative breast cancer (TNBC) is highly aggressive with limited treatment options, and resistance to doxorubicin (DOX) further compromises outcomes.
GPX™ Tutorial Series: Introduction to ACAT
In this video we'll be talking about Introduction to ACAT.
GPX™ Tutorial Series: PDPlus Module
In this video we'll be talking about PDPlus Module.
GPX™ Tutorial Series: IVIVCPlus Module
In this video we'll be talking about IVIVCPlus Module.