November 2020 News/Events


Featured Webinar Replay:

Dr. Marv Waldman walks you through the AIDD™ module – the most highly-automated customizable protocol commercially available!

ADMET Predictor APX



Featured “How-To” Videos:

Gastroplus tutorial



ACOP American Conference on Pharmacometrics 2020

ACoP Conference   Nov.9 – 13, 2020

Posters Presentations:

  • Comparison of pharmacokinetics and QTc effect of Quizartinib in Japanese and non-Japanese patients with Relapsed/Refractory (R/R) FLT3-ITD positive acute myeloid leukemia (AML) using population pharmacokinetic (PopPK) analyses
  • Development of Quantitative Systems Toxicology Model to Predict Drug Induced Acute Kidney Injury via mtDNA Depletion Pathway
  • Modeling Insights on Species Differences in Response to CD8+ T cell-mediated Liver Injury
  • Representation of Efavirenz-mediated Drug-Induced Liver Injury (DILI) Using Quantitative Systems Toxicology (QST)
  • Mathematically modeling CD8+ T cell-mediated drug-induced liver injury (DILI): from ovalbumin (OVA) to amodiaquine in mice
  • Quantitative Systems Toxicology Modeling Supports Safety Determination for Ubrogepant, a Novel CGRP Inhibitor
  • Mechanistic Modeling of Cyclosporine A-induced Acute Kidney Injury with RENAsym™
  • A library of tumor growth and tumor growth inhibition models for the MonolixSuite
  • Simulation of first-in-human using an allometrically scaled population mechanistic TMDD model with preclinical monkey data
  • Implementation of the C-QTc study using MonolixSuite applications
  • GUI: a flexible and user-friendly application for simulations

AAPS PharmSci 360 2020

AAPS Conference    Nov. 2 – 5, 2020

Rapid Fire Sessions:

Tuesday, Nov. 3, 9-9:45 AM EST
Clinical Pharmacology Driving Innovative Trial Design
Kevin Dykstra – Vice President, Consulting Services

Wednesday, Nov. 4, 4–4:15 PM EST
Hepatotoxicity of Compound V Evaluated with Quantitative Systems Toxicology
Vinal V. Lakhani – Scientist I

PharmSci360 posters:

  1. *Best Abstract Award Winners: PBBM Analysis of the In Vivo Behavior of Amorphous Solid Dispersions Based on Water-Soluble versus Water-Insoluble Carriers: A Fenofibrate Case Study
  2. *Best Abstract Award Winner: Physiologically Based Pharmacokinetic Modeling of Oxybate: The Role of Counter-ions in Gastrointestinal Absorption
  3. Physiologically-Based Pharmacokinetic Model to Describe the Pharmacokinetics of Crushed Morphine Sulfate and Naltrexone Hydrochloride Extended-Release Capsules with Abuse Deterrent Properties
  4. Modeling the Impact of Amorphous Drug-Polymer Colloids on the Absorption of Poorly Water Soluble Drugs
  5. Pharmacokinetic Profile and Physiologically Based Pharmacokinetic Modeling of Matrine in Healthy Human Plasma and Saliva
  6. Quantitative Systems Toxicology Identifies the Mechanism and Data Gaps for Evaluating the Hepatotoxicity of Compound V
  7. Quantitative Systems Toxicology (DILIsym) Modeling of the Acetaminophen (Paracetamol) Mode of Action (MOA) Pathway for Hepatotoxicity Supports that Acetaminophen Is Not a Carcinogenic Hazard in Humans
  8. Quantitative Systems Toxicology Modeling Using DILIsym Suggests That Drug-Induced Liver Injury Can Be Enhanced by Co-administered Drugs and Mitigated by Mitochondrial Biogenesis
  9. Application of Minimal Physiologically Based Pharmacokinetic Model for Insulin: A Population Analysis
  10. Hybrid CFD-PBPK Model for Prediction of Systemic PK Following Nasal Insufflation of Milled Oxycodone Hydrochloride Extended-Release Tablets
  11. Applying Computational Prediction of Biorelevant Solubility in Dispersions of Self-Emulsifying Lipid-Based Formulations to Predict Dose Number

Drop a Business Card & Schedule a Meeting in booth VB1921 (click hereco-hosted by:
Arlene PadronBrett HowellDan O’ConnorCherylann IagattaEric JamoisGrace FraczkiewiczJames MullinJasmina NovakovicJoel OwenKe SzetoKyunghee YangMichael BolgerSandra Suarez-Sharp, and William van Osdol.

Gastroplus ADMET Predictor Lixoft

Now Available for Download

APX – Powerful ADMET Property Estimation, at your fingertips!

GastroPlus v9.8 – Confirm much more than your “gut instinct” with enhancements to all validated non-oral delivery route models!

MonolixSuite – Take your modeling and simulation to the next level!

Academic Licensing

Academic/Reference Site License Opportunities

Simulations Plus offers special academic pricing and licensing options for accredited institutions.

VIRAL Kinetics and Epidemiology

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Simulations Plus Monthly News & Events

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