In systems biology, we often speak of emergence—how complex systems yield behaviors not apparent from their individual parts.

Simulations Plus Announces Preliminary Third Quarter Fiscal 2025 Revenue
Updates fiscal 2025 revenue guidance range
Third quarter fiscal 2025 full results to be released on July 2, 2025, with conference call at 5 p.m. ET

Simulations Plus Announces Preliminary Third Quarter Fiscal 2025 Revenue
Updates fiscal 2025 revenue guidance range
Third quarter fiscal 2025 full results to be released on July 2, 2025, with conference call at 5 p.m. ET

Reversal of a Synthetic Opioid Overdose: Insights From a Validated Translational Model
Synthetic opioids are linked to >90 % of opioid overdose deaths in the United States.

Tissue Distribution and Pharmacokinetic Characteristics of Aztreonam Based on Multi-Species PBPK Model
As a monocyclic β-lactam antibiotic, aztreonam has regained attention recently because combining it with β-lactamase inhibitors helps fight drug-resistant bacteria.

ADMET Predictor® 13 Product Brochure
Proven algorithms. Premium data. Predictions you can rely on.

How to Improve Your Drug Candidate Quality Without Adding New Steps to Your Program
As every researcher in early development knows, there is constant pressure to identify high-quality drug candidates—while also increasing the speed and efficiency of the discovery process.

Navigating Synthon Space: Property-Driven Molecular Optimization for Pharmacokinetics
The Complexity of Chemical Space

AI & Adaptive Learning: A New Era in Clinical Trial Optimization, Protocol Compliance and Risk Based Monitoring
In this webinar, Dr. Brad Stefanovic, VP, Head of Clinical Innovation at Simulations Plus, discusses how biotechs and big pharma alike can stretch their clinical trials dollars while optimizing key areas for compliance and success.

Beyond the Linear Model: Fully Automated Concentration-QT Analysis and Reporting
Objective 1: Extend the linear model to nonlinear and delayed-effect models
Objectiv 2: Automation of data preparation, model selection, and reporting

mlxDesignEval: A Novel R Package for Design Evaluation Based on MonolixSuite
Develop an R package for design evaluation which can use Monolix or Simulx projects as input

Improvements in Data Quality Can Boost Efficiency and Reduce Development Costs: Findings from a Survey of Pharmacometric CROs
Modern drug development, which can take up to 15 years and cost as much as $11 billion USD, relies heavily on high-quality data.

Improvements in Data Quality Can Boost Efficiency and Reduce Development Costs: Findings from a Survey of Pharmacometric CROs
Modern drug development, which can take up to 15 years and cost as much as $11 billion USD, relies heavily on high-quality data1. Recognizing the criticality of attaining quality data that is easily convertible to analysis-ready datasets, a survey was developed to obtain baseline information on data quality and data standards, largely from a CRO perspective.

Prediction of Clinical Outcomes in a Heterogenous NSCLC Virtual Patient Population: a Quantitative Systems Pharmacology (QSP) Approach
Non-small cell lung cancer (NSCLC) is a major cause of mortality in the United States[1].

Quantitative Systems Toxicology (QST) Modeling Using BIOLOGXsym and Mechanistic Toxicity Data From a Biomimetic Liver Microphysiology System Predicts Biologics-induced Liver Injury
While biologics offer promise in addressing a range of unmet medical needs, clinically observed BILI events are concerning for drug developers, health care providers and patients.

ADMET Predictor® 13: Predict & Build with Confidence
ADMET Predictor 13 is almost here—and in this webinar, you’ll see how it gives your organization the First-to-Invent Advantage! Drs. David Miller, Vice President, ADMET Cheminformatics, and Michael Lawless, Sr. Principal Scientist, Cheminformatics Solutions walk you through the latest version of the software...

Predicting Brinzolamide Ocular Response in Humans Using an Ocular PBPK-PD Modeling and Simulation
The development of generic ophthalmic drug products indicated for intraocular pressure (IOP) reduction typically relies on comparative pharmacodynamic (PD) endpoint bioequivalence (BE) studies.

Intestinal Secretion Is a Potentially Important Clearance Mechanism for Low Metabolic Clearance Compounds
Intestinal excretion/secretion (IE) from the systemic circulation via the enterocytes into the intestinal lumen has traditionally been considered a minor clearance (CL) pathway.

Framework for Classifying Chemicals for Repeat Dose Toxicity Using NAMs
EPAA’s ‘NAM Designathon 2023’ challenge for human toxicity sought to identify a classification system capable of categorising chemicals based on their bioactivity and bioavailability properties determined using non-animal methodologies (Worth et al. 2025).

Multi-target Property Prediction and Optimization Using Latent Spaces of Generative Model
Multi-target property prediction has the potential to improve generalization by exploiting the positive transfer between targets.