Improvements to the GastroPlus® platform will increase its impact in driving research and regulatory decisions on dermatological products
Pharmacokinetics of Pantoprazole and Pantoprazole Sulfone in Goats After Intravenous Administration: A Preliminary Report
Ruminant species are at risk of developing abomasal ulceration, but there is a lack of pharmacokinetic data for anti-ulcer therapies, such as the proton pump inhibitor pantoprazole, in...
Developing a PBPK modeling approach for evaluating drug product performance in infants based on adults data
Understanding drug and drug formulation performance in relation to the prandial conditions is essential for ensuring the safety and efficacy of products to be administered to pediatric patients, especially newborns...
Establishing the Bioequivalence Safe Space for Immediate-Release Oral Dosage Forms Using Physiologically Based Biopharmaceutics Modeling (PBBM): Case Studies
For oral drug products, in vitro dissolution is the most used surrogate of in vivo dissolution and absorption.
Establishing the Bioequivalence Safe Space for Immediate-Release Oral Dosage Forms using Physiologically Based Biopharmaceutics Modeling (PBBM): Case Studies
For oral drug products, in vitro dissolution is the most used surrogate of in vivo dissolution and absorption.
Integrated Testing Strategy for the Safety of Botanical Ingredients: A Case Study with German Chamomile Constituents
Introduction: chamomile is a botanical ingredient commonly used in cosmetics, thus determination of skin sensitization effects of German chamomile constituents is critical for the...
ADMET Predictor® 10.3 (APX.3): Flagship machine learning platform for ADMET modeling
Panelist David Miller, VP of ADMET Cheminformatics will show some of the new features in APX.3, including details about a new REST API for deployment via Web services.
September 2021 GastroPlus Newsletter
Hooray!... We are finally going to be attending a real conference, in-person, “non-virtually”!
Comparison of in vitro, in vivo, and in silico bioavailability results of different prednisone tablet formulations to assess the feasibility of possible biowaiver
The immediate-release solid oral products containing very soluble and permeable drugs are candidates for the biowaiver process.
Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling to Evaluate the Absorption of Midazolam Rectal Gel
We aimed to 1) develop physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models of a novel midazolam rectal gel in healthy adults, 2) assess the contribution of different physiologically relevant...
Integration of Clinical and Scientific Principles in the Teaching of Drug-Drug Interactions
Evaluation of drug-drug interactions (DDIs) is an integral part of pharmacy practice worldwide.
Current Regulatory Requirements for Biosimilars in Six Member Countries of BRICS-TM: Challenges and Opportunities
The aim of the study was to identify, interpret, and compare the current perspectives of regulatory agencies in six member countries of BRICS-TM (Brazil, Russia, India, China, South Africa, Turkey, and Mexico) on the different criteria used for biosimilar development and marketing authorisation process.
Simulations Plus to Participate in BofA Securities and Oppenheimer Investor Conferences
Simulations Plus, Inc. (Nasdaq: SLP), a leading provider of modeling and simulation software and services for pharmaceutical safety and efficacy, today announced that chief executive officer Shawn O’Connor will be...
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption
Physiologically based pharmacokinetic (PBPK) modelling has evolved to accommodate different routes of drug administration and enables prediction of drug concentrations in tissues as well as plasma.
Development of PBPK model for intra-articular injection in human: methotrexate solution and rheumatoid arthritis case study
A physiologically based model describing the dissolution, diffusion, and transfer of drug from the intra-articular (IA) space to the plasma, was developed for GastroPlus v9.8.
Current computer-aided drug design methodologies in discovery of novel drug candidates for neuropsychiatric and inflammatory diseases
Drug discovery and development is a very challenging, expensive and time-consuming process.
The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development
Computer-based (in silico) modeling & simulation tools have been embraced in different fields of pharmaceutics for a variety of applications.