Deep eutectic liquid as transdermal delivery vehicle of Risperidone

Deep eutectic liquid as transdermal delivery vehicle of Risperidone

Authors: Daadoue S, Al-Remawi M, Al-Mawla L, Idkaidek N, Khalid RM, Al-Akayleh F
Publication: Journal Molecular Liquids
Keywords: dermal absorption, gastroplus, in vitro skin penetration, PBPK modeling, Skin permeation, topical administration
Software: GastroPlus®

The work outlined herein describes an evaluation of a green solvent working as a drug solubility and penetration enhancer made up of a deep eutectic system (DES) composed of menthol (MN) and capric acid (CA).

A phase I dose-escalation study of oxaliplatin delivered via a laparoscopic approach using pressurised intraperitoneal aerosol chemotherapy for advanced peritoneal metastases of gastrointestinal tract cancers

A phase I dose-escalation study of oxaliplatin delivered via a laparoscopic approach using pressurised intraperitoneal aerosol chemotherapy for advanced peritoneal metastases of gastrointestinal tract cancers

Authors: Dumont F, Raoul JL, Kepenekian V, Lelievre B, Boisdron-Celle M, Hiret S, Senellart H, Pein F, Blanc-Lapierre A, Raimbourg J, Thibaudeau E, Passot C
Publication: Eur J Cancer
Keywords: haematologic, intraperitoneal, pharmacokinetics, PIPAC, tumours
Software: PKanalix®
Division: Clinical Pharmacology and Pharmacometrics (CPP)

The objectives were to define the maximum tolerated dose (MTD), safety profile and pharmacokinetics (PKs) of intraperitoneal oxaliplatin delivered by pressurized intraperitoneal...

Development of physiologically-based pharmacokinetic models for standard of care and newer tuberculosis drugs

Development of physiologically-based pharmacokinetic models for standard of care and newer tuberculosis drugs

Authors: Humphries H, Almond L, Berg A, Gardner I, Hatley O, Small B, Zhang M, Jamei M, Romero K, Pan X
Publication: CPT Pharmacometrics Syst Pharmacol
Keywords: and rifapentine, cycloserine, ethambutol, ethionamide, isoniazid, kanamycin, Linezolid, physiologically based pharmacokinetic modeling, pyrazinamide, Rifampicin
Software: GastroPlus®
Division: PBPK

Tuberculosis (TB) remains a global health problem and there is an ongoing effort to develop more effective therapies and new combination regimes that can reduce duration of treatment.