With the Additional Dosage Routes Module, simulating concentrations through these sites is managed through our easy-to-use interface. Mechanistic, physiologically-based models are provided for each tissue, for different species. You can also customize your own physiology by entering available information into the program. These models are linked with either compartmental or physiologically-based pharmacokinetics (PBPK) & physiologically based biopharmaceutics modeling (PBBM) in GastroPlus, so you may predict your drug’s distribution and elimination once it enters into the systemic circulation.
For all of these PBPK delivery models, standard GastroPlus features, including the Population Simulator and Parameter Sensitivity Analysis, can be utilized. Plus, load measured in vivo PK data, for local tissues, to optimize and validate your models. And, finally, as with other GastroPlus modules, there is no equation or code writing required.